| First Author | Portal-Núñez S | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 14 | Pages | 3095-100 |
| PubMed ID | 20621835 | Mgi Jnum | J:162393 |
| Mgi Id | MGI:4818825 | Doi | 10.1016/j.febslet.2010.05.047 |
| Citation | Portal-Nunez S, et al. (2010) Alterations of the Wnt/beta-catenin pathway and its target genes for the N- and C-terminal domains of parathyroid hormone-related protein in bone from diabetic mice. FEBS Lett 584(14):3095-100 |
| abstractText | Type 1 diabetes mellitus (T1D) is associated with bone loss. Given that the Wnt/beta-catenin pathway is a major regulator of bone accrual, we assessed this pathway in mice with streptozotozin-induced T1D. In diabetic mouse long bones, we found alterations favouring the suppression of this pathway by using PCR arrays and beta-catenin immunostaining. Downregulation of sclerostin, an inhibitor of this pathway, also occurred, and related to increased osteocyte apoptosis. Our data show that both N- and C-terminal parathyroid hormone-related peptide fragments might exert osteogenic effects in this setting by targeting several genes of this pathway and increasing beta-catenin in osteoblastic cells. |
