| First Author | Potier M | Year | 2010 |
| Journal | Biochem Biophys Res Commun | Volume | 397 |
| Issue | 1 | Pages | 42-7 |
| PubMed ID | 20519134 | Mgi Jnum | J:162418 |
| Mgi Id | MGI:4818850 | Doi | 10.1016/j.bbrc.2010.05.046 |
| Citation | Potier M, et al. (2010) Altered SK3/KCa2.3-mediated migration in adenomatous polyposis coli (Apc) mutated mouse colon epithelial cells. Biochem Biophys Res Commun 397(1):42-7 |
| abstractText | Lost of adenomatous polyposis coli gene (Apc) disturbs the migration of intestinal epithelial cells but the mechanisms have not been fully characterized. Since we have demonstrated that SK3/KCa2.3 channel promotes cancer cell migration, we hypothesized that Apc mutation may affect SK3/KCa2.3 channel-mediated colon epithelial cell motility. We report evidence that SK3/KCa2.3 channel promotes colon epithelial cells motility. Following Apc mutation SK3/KCa2.3 expression is largely reduced leading to a suppression of the SK3/KCa2.3 channel mediated-cell migration. Our findings reveal a previously unknown function of the SK3/KCa2.3 channel in epithelial colonic cells, and suggest that Apc is a powerful regulator SK3/KCa2.3 channel. |
