| First Author | Jones M | Year | 2010 |
| Journal | J Immunol | Volume | 185 |
| Issue | 6 | Pages | 3583-92 |
| PubMed ID | 20713884 | Mgi Jnum | J:163819 |
| Mgi Id | MGI:4830008 | Doi | 10.4049/jimmunol.1001535 |
| Citation | Jones M, et al. (2010) IL-10 restricts memory T cell inflation during cytomegalovirus infection. J Immunol 185(6):3583-92 |
| abstractText | The beta-herpesvirus CMV induces a substantial and progressive expansion of virus-specific memory CD8 T cells, which protect the host against viral reactivation from latency. In this paper, we report that this expansion, or 'inflation,' of memory T cells is amplified dramatically during mouse CMV infection of IL-10 knockout (IL-10(-/-)) mice. T cells from IL-10(-/-) mice were oligoclonal, exhibited a highly activated phenotype, expressed antiviral cytokines, and degranulated in response to cognate Ag encounter ex vivo. Moreover, latent viral load was reduced in IL-10(-/-) mice. Importantly, these results were recapitulated by IL-10R blockade during chronic/latent infection of wild-type mice. These data demonstrate that regulatory immune mechanisms can influence CMV-specific T cell memory and suggest a possible rationale for the acquisition of functional IL-10 orthologs by herpesviruses. |
