| First Author | Hofmann ER | Year | 2010 |
| Journal | J Cell Sci | Volume | 123 |
| Issue | Pt 16 | Pages | 2781-91 |
| PubMed ID | 20663920 | Mgi Jnum | J:164246 |
| Mgi Id | MGI:4830943 | Doi | 10.1242/jcs.070250 |
| Citation | Hofmann ER, et al. (2010) Identification and characterization of GRIM-1, a cell-death-associated gene product. {RETRACTED}. J Cell Sci 123(Pt 16):2781-91 |
| abstractText | Using a genome-wide technical knockout, we isolated a newly identified set of GRIM (genes associated with retinoid-interferon-induced mortality) genes; GRIM genes mediate IFN- and retinoic-acid (RA)-induced cell death. Here, we describe the isolation and characterization of one such gene, GRIM-1. Three proteins, with identical C-termini, were produced from the GRIM-1 open reading frame when this gene was transcribed and translated in vitro. These protein isoforms, designated GRIM-1alpha, GRIM-1beta and GRIM-1gamma, differentially suppressed growth via apoptosis in various cell lines. We also show that a caspase-dependent mechanism generates the proapoptotic GRIM-1 isoforms. Lastly, GRIM-1 isoforms differentially blocked maturation of 18S ribosomal RNA, consistent with their respective growth-suppressive ability. Together, these studies identified a novel protein involved in growth suppression and cell death. |
