| First Author | García-Andrés C | Year | 2010 |
| Journal | Dev Dyn | Volume | 239 |
| Issue | 10 | Pages | 2769-77 |
| PubMed ID | 21038449 | Mgi Jnum | J:165546 |
| Mgi Id | MGI:4837747 | Doi | 10.1002/dvdy.22413 |
| Citation | Garcia-Andres C, et al. (2010) Comparative expression pattern analysis of the highly conserved chemokines SDF1 and CXCL14 during amniote embryonic development. Dev Dyn 239(10):2769-77 |
| abstractText | Chemokines are secreted proteins with essential roles in leukocyte trafficking and cell migration during embryogenesis. CXCL14 displays a degree of evolutionary conservation unmatched by any other chemokine except for SDF1(CXCL12). However, its role during embryogenesis has not been studied. Here we describe the expression pattern of mouse and chicken CXCL14 during embryogenesis and compare it with that of SDF1. CXCL14 is widely expressed in embryonic ectoderm and shows a restricted and dynamic expression pattern in paraxial mesoderm, mesonephros, neural tube, and limbs. During limb development, CXCL14 marks a unique connective tissue subset that surrounds developing tendons. Comparison of CXCL14 and SDF1 reveals mostly non-overlapping or complementary expression patterns, suggesting an interactive regulation of developmental processes by these two chemokines. Our study identifies CXCL14 as a novel marker of tendon connective tissue and provides a conceptual framework for the coordinated action of two highly conserved chemokines in embryonic development. Developmental Dynamics 239:2769-2777, 2010. (c) 2010 Wiley-Liss, Inc. |
