First Author | Triboulet R | Year | 2010 |
Journal | Nat Cell Biol | Volume | 12 |
Issue | 10 | Pages | 928-9 |
PubMed ID | 20885420 | Mgi Jnum | J:166462 |
Mgi Id | MGI:4845806 | Doi | 10.1038/ncb1010-928 |
Citation | Triboulet R, et al. (2010) Pumilio turns on microRNA function. Nat Cell Biol 12(10):928-9 |
abstractText | Pumilio proteins PUM1 and PUM2 are shown to regulate microRNA-dependent gene silencing by induction of a conformational switch in the 3' untranslated region of p27 mRNA. This conformational change is required for efficient microRNA-mediated repression of this cell-cycle regulator in rapidly proliferating cells. |