| First Author | da Silva Xavier G | Year | 2010 |
| Journal | Biochem Biophys Res Commun | Volume | 402 |
| Issue | 2 | Pages | 252-7 |
| PubMed ID | 20934404 | Mgi Jnum | J:166930 |
| Mgi Id | MGI:4850211 | Doi | 10.1016/j.bbrc.2010.10.010 |
| Citation | da Silva Xavier G, et al. (2010) ChREBP regulates Pdx-1 and other glucose-sensitive genes in pancreatic beta-cells. Biochem Biophys Res Commun 402(2):252-7 |
| abstractText | Carbohydrate responsive element-binding protein (ChREBP) is a transcription factor whose expression and activity are increased in pancreatic beta-cells maintained at elevated glucose concentrations. We show here that ChREBP inactivation in clonal pancreatic MIN6 beta-cells results in an increase in Pdx-1 expression at low glucose and to a small, but significant, increase in Ins2, GcK and MafA gene expression at high glucose concentrations. Conversely, adenovirus-mediated over-expression of ChREBP in mouse pancreatic islets results in decreases in Pdx-1, MafA, Ins1, Ins2 and GcK mRNA levels. These data suggest that strategies to reduce ChREBP activity might protect against beta-cell dysfunction in type 2 diabetes. |
