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Publication : The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity.

First Author  Miller GM Year  2011
Journal  J Neurochem Volume  116
Issue  2 Pages  164-76
PubMed ID  21073468 Mgi Jnum  J:167622
Mgi Id  MGI:4868650 Doi  10.1111/j.1471-4159.2010.07109.x
Citation  Miller GM (2011) The emerging role of trace amine-associated receptor 1 in the functional regulation of monoamine transporters and dopaminergic activity. J Neurochem 116(2):164-76
abstractText  It is now recognized that trace amine associated-receptor 1 (TAAR1) plays a functional role in the regulation of brain monoamines and the mediation of action of amphetamine-like psychostimulants. Accordingly, research on TAAR1 opens the door to a new avenue of approach for medications development to treat drug addiction as well as the spectrum of neuropsychiatric disorders hallmarked by aberrant regulation of brain monoamines. This overview focuses on recent studies which reveal a role for TAAR1 in the functional regulation of monoamine transporters and the neuronal regulatory mechanisms that modulate dopaminergic activity.
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