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Publication : Controlled demolition: Smurf1 regulates neuronal polarity by substrate switching.

First Author  Stiess M Year  2011
Journal  Neuron Volume  69
Issue  2 Pages  183-5
PubMed ID  21262456 Mgi Jnum  J:168145
Mgi Id  MGI:4887278 Doi  10.1016/j.neuron.2011.01.007
Citation  Stiess M, et al. (2011) Controlled demolition: smurf1 regulates neuronal polarity by substrate switching. Neuron 69(2):183-5
abstractText  During axon specification, growth promoting proteins localize selectively to the growing axon. In this issue of Neuron, Cheng et al. report how selective protein degradation, controlled by a substrate switch of the ubiquitin ligase Smurf1, specifies Par6 and RhoA localization and thereby regulates neuronal polarity.
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