| First Author | Li RH | Year | 2010 |
| Journal | Physiol Genomics | Volume | 42A |
| Issue | 4 | Pages | 228-34 |
| PubMed ID | 20858711 | Mgi Jnum | J:168352 |
| Mgi Id | MGI:4888077 | Doi | 10.1152/physiolgenomics.00044.2010 |
| Citation | Li RH, et al. (2010) Epistasis contributes to the genetic buffering of plasma HDL cholesterol in mice. Physiol Genomics 42A(4):228-34 |
| abstractText | Stressful environmental factors, such as a high-fat diet, can induce responses in the expression of genes that act to maintain physiological homeostasis. We observed variation in plasma concentrations of high-density lipoprotein (HDL) cholesterol across inbred mouse strains in response to high dietary fat intake. Several strains, including C57BL/6J, have stable levels of plasma HDL independent of diet, whereas other strains, including DBA2/J, show marked changes in plasma HDL. To explore this phenomenon further, we used publicly available data from a C57BL/6J x DBA/2J intercross to identify genetic factors that associate with HDL under high-fat diet conditions. Our analysis identified an epistatic interaction that plays a role in the buffering of HDL levels in C57BL/6J mice, and we have identified Arl4d as a candidate gene that mediates this effect. Structural modeling further elucidates the interaction of genetic factors that contribute to the robustness of HDL in response to high-fat diet in the C57BL/6J strain. |
