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Publication : Glioma models: new GEMMs add "class" with genomic and expression correlations.

First Author  Maire CL Year  2011
Journal  Cancer Cell Volume  19
Issue  3 Pages  295-7
PubMed ID  21397851 Mgi Jnum  J:169932
Mgi Id  MGI:4943608 Doi  10.1016/j.ccr.2011.02.018
Citation  Maire CL, et al. (2011) Glioma Models: New GEMMs Add 'Class' with Genomic and Expression Correlations. Cancer Cell 19(3):295-7
abstractText  Malignant gliomas are characterized by accumulated aberrations affecting TP53, PTEN, and RB1 signaling. In this issue, Chow et al. discover that combinatorial loss of these tumor suppressors in mice induces gliomas with unexpected degrees of similarity to human pathologic, genomic, and expression subclasses recently revealed by large-scale genomic studies.
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