| First Author | Byun EH | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 5 | Pages | 814-20 |
| PubMed ID | 21320497 | Mgi Jnum | J:170332 |
| Mgi Id | MGI:4946331 | Doi | 10.1016/j.febslet.2011.02.010 |
| Citation | Byun EH, et al. (2011) Green tea polyphenol epigallocatechin-3-gallate inhibits TLR2 signaling induced by peptidoglycan through the polyphenol sensing molecule 67-kDa laminin receptor. FEBS Lett 585(5):814-20 |
| abstractText | Here we show the molecular basis for the inhibition of peptidoglycan (PGN)-induced TLR2 signaling by a major green tea polyphenol epigallocatechin-3-gallate (EGCG). Recently, we identified the 67-kDa laminin receptor (67LR) as the cell-surface EGCG receptor. Anti-67LR antibody treatment or silencing of 67LR resulted in abrogation of the inhibitory action of EGCG on PGN-induced production of pro-inflammatory mediators and activation of mitogen-activated protein kinases. Silencing of Toll-interacting protein (Tollip), a negative regulator of TLR signaling impaired the TLR2 signaling inhibitory activity of EGCG, suggesting that TLR2 response could be inhibited by EGCG via 67LR and Tollip. |
