| First Author | Sakakibara H | Year | 2011 |
| Journal | Behav Brain Res | Volume | 220 |
| Issue | 2 | Pages | 354-7 |
| PubMed ID | 21354214 | Mgi Jnum | J:171456 |
| Mgi Id | MGI:4949978 | Doi | 10.1016/j.bbr.2011.02.023 |
| Citation | Sakakibara H, et al. (2011) Feeble awake effects of plasminogen activator inhibitor type-1 in mice. Behav Brain Res 220(2):354-7 |
| abstractText | Plasminogen activator inhibitor-type 1 (PAI-1) is involved in the fibrinolytic system and shows its increased levels in diseases, e.g., obesity and sleep apnea syndrome. The aim of the study is to investigate whether PAI-1 affects sleep-wake patterns in mice. When recombinant mouse PAI-1 was administered intraperitoneally, only rapid but short increases in time spent awake were observed after 20 or 100mug/kg, although its plasma concentration was kept high for an hour. The results suggest that PAI-1 may serve its role rather as a marker than an initiator of disturbed sleep. |
