| First Author | Ahnaou A | Year | 2011 |
| Journal | Behav Brain Res | Volume | 221 |
| Issue | 1 | Pages | 246-52 |
| PubMed ID | 21392539 | Mgi Jnum | J:171723 |
| Mgi Id | MGI:4950829 | Doi | 10.1016/j.bbr.2011.03.004 |
| Citation | Ahnaou A, et al. (2011) Disruption of glycogen synthase kinase-3-beta activity leads to abnormalities in physiological measures in mice. Behav Brain Res 221(1):246-52 |
| abstractText | Dysregulation of glycogen synthase kinase-3-beta (GSK-3beta) signaling pathways is thought to underlie the pathophysiology of mood disorders. In order to demonstrate that the loss of normal GSK-3beta activity results in disturbances of physiological measures, we attempted to determine whether sleep-wake architecture, circadian rhythms of core body temperature and activity were altered in transgenic mice overexpressing GSK-3beta activity specifically in the brain. Cortical electroencephalographic activity, body temperature (BT) and body locomotor activity (LMA) were continuously monitored using a biopotential telemetry probe. Normal circadian patterns were maintained for different measurements in both genotypes. No differences were found in total time spent asleep and waking over the 24-h recording session. However, transgenic animals overexpressing GSK-3beta showed alteration in sleep continuity characterized by an increases in number of non rapid eye movement (NREM) sleep episodes (GSK-3beta, 227.2+/-1.7 vs. WT, 172.6+/-1.4, p<0.05) and decreases in mean episode duration (GSK-3beta, 3.0+/-0.1 vs. WT, 4.4+/-0.2, p<0.05). Additionally, transgenic animals exhibited marked enhancement of basal LMA and BT levels during the first part of the dark period, under both light-dark and free running dark-dark circadian cycles. Our findings indicate that transgenic mice overexpressing GSK-3beta activity exhibit severe fragmentation of sleep-wake cycle during both the light and dark periods, without showing deviancy in total durations of vigilance states. The results strongly suggest that GSK-3beta activity is elemental for the maintenance of circadian motor behavior levels required for proper regulation of BT and sleep-wake organization. |
