| First Author | Tuteja G | Year | 2008 |
| Journal | Nucleic Acids Res | Volume | 36 |
| Issue | 12 | Pages | 4149-57 |
| PubMed ID | 18556755 | Mgi Jnum | J:173063 |
| Mgi Id | MGI:5009524 | Doi | 10.1093/nar/gkn366 |
| Citation | Tuteja G, et al. (2008) Cis-regulatory modules in the mammalian liver: composition depends on strength of Foxa2 consensus site. Nucleic Acids Res 36(12):4149-57 |
| abstractText | Foxa2 is a critical transcription factor that controls liver development and plays an important role in hepatic gluconeogensis in adult mice. Here, we use genome-wide location analysis for Foxa2 to identify its targets in the adult liver. We then show by computational analyses that Foxa2 containing cis-regulatory modules are not constructed from a random assortment of binding sites for other transcription factors expressed in the liver, but rather that their composition depends on the strength of the Foxa2 consensus site present. Genes containing a cis-regulatory module with a medium or weak Foxa2 consensus site are much more liver-specific than the genes with a strong consensus site. We not only provide a better understanding of the mechanisms of Foxa2 regulation but also introduce a novel method for identification of different cis-regulatory modules involving a single factor. |
