| First Author | Park JH | Year | 2011 |
| Journal | Cancer Lett | Volume | 310 |
| Issue | 1 | Pages | 53-60 |
| PubMed ID | 21741167 | Mgi Jnum | J:174546 |
| Mgi Id | MGI:5139954 | Doi | 10.1016/j.canlet.2011.06.013 |
| Citation | Park JH, et al. (2011) Non-invasive monitoring of hepatocellular carcinoma in transgenic mouse with bioluminescent imaging. Cancer Lett 310(1):53-60 |
| abstractText | A small animal imaging system for hepatocellular carcinoma (HCC)-specific reporter gene expression will enable monitoring of carcinogenesis or therapeutic intervention in vivo. Transgenic mouse was developed in which firefly luciferase (fLuc) expression was controlled by the AFP enhancer/promoter. The bioluminescent signals of the transgenic neonates were strong at their liver region and decreased after birth. Bioluminescent imaging (BLI) of a transgenic mouse treated with N-nitrosodiethylamine revealed distinct fLuc activity in the liver and an increased pattern with time. The transgenic mouse model can be used to monitor AFP producing HCC by a chemical carcinogen in a live animal by BLI. |
