| First Author | Zhou W | Year | 2011 |
| Journal | Biochem Biophys Res Commun | Volume | 411 |
| Issue | 4 | Pages | 768-73 |
| PubMed ID | 21782789 | Mgi Jnum | J:175785 |
| Mgi Id | MGI:5287319 | Doi | 10.1016/j.bbrc.2011.07.022 |
| Citation | Zhou W, et al. (2011) Palladin is a novel binding partner of ILKAP in eukaryotic cells. Biochem Biophys Res Commun 411(4):768-73 |
| abstractText | Palladin was a novel binding partner of ILKAP in eukaryotic cells. Palladin's C-terminal fragment including only its last three Ig domains (residues 710-1106) and the PP2C domain of ILKAP (residues 108-392) were necessary and sufficient for their interaction. The biological significance of the interaction between palladin and ILKAP was that palladin recruited the cytoplasmic ILKAP to initiate ILKAP-induced apoptosis. Our results suggested that palladin played a specific role in modulating the subcellular localization of the cytoplasmic ILKAP and promoting the ILKAP-induced apoptosis. |
