| First Author | Granot Z | Year | 2011 |
| Journal | Cancer Cell | Volume | 20 |
| Issue | 3 | Pages | 300-14 |
| PubMed ID | 21907922 | Mgi Jnum | J:175970 |
| Mgi Id | MGI:5288078 | Doi | 10.1016/j.ccr.2011.08.012 |
| Citation | Granot Z, et al. (2011) Tumor entrained neutrophils inhibit seeding in the premetastatic lung. Cancer Cell 20(3):300-14 |
| abstractText | Primary tumors have been shown to prepare distal organs for later colonization of metastatic cells by stimulating organ-specific infiltration of bone marrow derived cells. Here we demonstrate that neutrophils accumulate in the lung prior to the arrival of metastatic cells in mouse models of breast cancer. Tumor-entrained neutrophils (TENs) inhibit metastatic seeding in the lungs by generating H(2)O(2) and tumor secreted CCL2 is a critical mediator of optimal antimetastatic entrainment of G-CSF-stimulated neutrophils. TENs are present in the peripheral blood of breast cancer patients prior to surgical resection but not in healthy individuals. Thus, whereas tumor-secreted factors contribute to tumor progression at the primary site, they concomitantly induce a neutrophil-mediated inhibitory process at the metastatic site. |
