| First Author | Sano T | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 17 | Pages | 2714-9 |
| PubMed ID | 21821028 | Mgi Jnum | J:175997 |
| Mgi Id | MGI:5288105 | Doi | 10.1016/j.febslet.2011.07.029 |
| Citation | Sano T, et al. (2011) Characterization of the threonine-phosphatase of mouse eyes absent 3. FEBS Lett 585(17):2714-9 |
| abstractText | Eyes absent (EYA) has tyrosine- and threonine-phosphatase activities in their C-terminal and N-terminal regions, respectively. Using various mutants of mouse EYA3, we showed that the 68-amino acid domain between positions 53 and 120 was necessary and sufficient for its threonine-phosphatase activity. Point mutations were then introduced, and residues Cys-56, Tyr-77, His-79, and Tyr-90 were essential for the EYA3s threonine-phosphatase. The 68-amino acid domain is not well conserved among the four mouse EYA members, but is evolutionally highly conserved in the orthologous EYA members of different species, suggesting that the threonine-phosphatase of EYA3 has a function distinct from that of the other EYAs. |
