| First Author | Nevoux J | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 17 | Pages | 2703-8 |
| PubMed ID | 21820436 | Mgi Jnum | J:176000 |
| Mgi Id | MGI:5288108 | Doi | 10.1016/j.febslet.2011.07.025 |
| Citation | Nevoux J, et al. (2011) Vasopressin, ATP and catecholamines differentially control potassium secretion in inner ear cell line. FEBS Lett 585(17):2703-8 |
| abstractText | A strict control of endolymph composition (high potassium, low sodium fluid) and volume is instrumental for a proper functioning of the inner ear. Alteration of endolymph homeostasis is proposed in the pathogenesis of Meniere's disease. However, the mechanisms controlling endolymph secretion remain elusive. By using the vestibular EC5v cells, we provide evidence for the presence of vasopressin, catecholamine and purinergic signaling pathways, coupled to adenylate cyclase, phosphoinositidase C and Ca(2+) activation. We demonstrate that vasopressin and catecholamines stimulate while ATP inhibits apical potassium secretion by EC5v cells. These results open new interesting perspectives for the management of inner ear diseases. |
