| First Author | Jin H | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 21 | Pages | 3457-64 |
| PubMed ID | 22001200 | Mgi Jnum | J:177499 |
| Mgi Id | MGI:5295316 | Doi | 10.1016/j.febslet.2011.10.002 |
| Citation | Jin H, et al. (2011) Effects of a novel peptide derived from human thrombomodulin on endotoxin-induced uveitis in vitro and in vivo. FEBS Lett 585(21):3457-64 |
| abstractText | Thrombomodulin (TM) is a single-transmembrane glycoprotein receptor for thrombin, which is best known as a cofactor for thrombin-mediated activation of anticoagulant protein C. C-type lectin-like domain (CTLD) of TM has distinct coagulation/fibrinolysis-independent anti-inflammatory properties. Here we found anti-inflammatory effects of a novel peptide (GC31) from CTLD of TM in endotoxin-induced uveitis, which was characterized by a reduction of leukocyte counts, protein concentration, tumor necrosis factor (TNF)-alpha and monocyte chemoattractant protein (MCP)-1 levels in aqueous humor. Through in vitro experiments, we further found that GC31 suppressed TNF-alpha and interleukin (IL)-6 expressions in lipopolysaccharide (LPS)-stimulated macrophage-like RAW264.7 cells and interrupted LPS-induced nuclear factor-kappaB (NF-kappaB) activation. These data indicate a beneficial role of peptide GC31 in preventing intraocular inflammatory response, especially uveitis. |
