| First Author | Liu S | Year | 2011 |
| Journal | Biochem Biophys Res Commun | Volume | 414 |
| Issue | 3 | Pages | 618-24 |
| PubMed ID | 21986534 | Mgi Jnum | J:178529 |
| Mgi Id | MGI:5299247 | Doi | 10.1016/j.bbrc.2011.09.131 |
| Citation | Liu S, et al. (2011) TNFalpha-induced up-regulation of miR-155 inhibits adipogenesis by down-regulating early adipogenic transcription factors. Biochem Biophys Res Commun 414(3):618-24 |
| abstractText | Tumor necrosis factor alpha (TNFalpha) is known to inhibit adipogenesis, but the molecular mechanism of this inhibition remains elusive. In the present study, we found that TNFalpha-induced inhibition of adipogenesis mainly occurs when 3T3-L1 preadipocytes are treated with TNFalpha within 2h induction of adipogenesis. We revealed that TNFalpha treatment results in the up-regulation of miR-155 through the NFkappaB pathway in 3T3-L1 cells. This overexpression of miR-155 may suppress the expression of C/EBPbeta and CREB by directly targeting their 3' untranslated regions (3' UTRs). Importantly, anti-miR-155 reduces the TNFalpha-induced inhibition of adipogenesis, whereas exogenous expression of mir-155 inhibits adipogenesis. Taken together, these findings reveal a novel role for TNFalpha in the regulation of anti-adipogenic miRNAs. |
