| First Author | Choi SH | Year | 2011 |
| Journal | Biochem Biophys Res Commun | Volume | 416 |
| Issue | 1-2 | Pages | 70-5 |
| PubMed ID | 22086179 | Mgi Jnum | J:179206 |
| Mgi Id | MGI:5301460 | Doi | 10.1016/j.bbrc.2011.10.145 |
| Citation | Choi SH, et al. (2011) Methionine sulfoxide reductase A regulates cell growth through the p53-p21 pathway. Biochem Biophys Res Commun 416(1-2):70-5 |
| abstractText | MsrA is an oxidoreductase that catalyzes the stereospecific reduction of methionine-S-sulfoxide to methionine. Although MsrA is well-characterized as an antioxidant and has been implicated in the aging process and cellular senescence, its roles in cell proliferation are poorly understood. Here, we report a critical role of MsrA in normal cell proliferation and describe the regulation mechanism of cell growth by this protein. Down-regulation of MsrA inhibited cell proliferation, but MsrA overexpression did not promote it. MsrA deficiency led to an increase in p21, a major cyclin-dependent kinase inhibitor, thereby causing cell cycle arrest at the G(2)/M stage. While protein levels of p53 were not altered upon MsrA deficiency, its acetylation level was significantly elevated, which subsequently activated p21 transcription. The data suggest that MsrA is a regulator of cell growth that mediates the p53-p21 pathway. |
