| First Author | Schmid F | Year | 2011 |
| Journal | FEBS Lett | Volume | 585 |
| Issue | 22 | Pages | 3544-8 |
| PubMed ID | 22020217 | Mgi Jnum | J:180266 |
| Mgi Id | MGI:5305917 | Doi | 10.1016/j.febslet.2011.10.017 |
| Citation | Schmid F, et al. (2011) CD38: a NAADP degrading enzyme. FEBS Lett 585(22):3544-8 |
| abstractText | The role of the multifunctional enzyme CD38 in formation of the Ca(2+)-mobilizing second messenger nicotinic acid adenine dinucleotide phosphate (NAADP) was investigated. Gene silencing of CD38 did neither inhibit NAADP synthesis in intact Jurkat T cells nor in thymus or spleen obtained from CD38 knock out mice. In vitro, both NAADP formation by base-exchange and degradation to 2-phospho adenosine diphosphoribose were efficiently decreased. Thus in vivo CD38 appears to be a NAADP degrading rather than a NAADP forming enzyme, perhaps avoiding desensitizing NAADP levels in intact cells. |
