| First Author | Murakami K | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 4 | Pages | 319-24 |
| PubMed ID | 22265692 | Mgi Jnum | J:181921 |
| Mgi Id | MGI:5314436 | Doi | 10.1016/j.febslet.2012.01.010 |
| Citation | Murakami K, et al. (2012) Follistatin-related protein/follistatin-like 1 evokes an innate immune response via CD14 and toll-like receptor 4. FEBS Lett 586(4):319-24 |
| abstractText | Follistatin-related protein (FRP)/follistatin-like 1 (FSTL1) has multi-specific binding nature especially with TGF-beta superfamily proteins, and thereby modulates organ development. However, its function in immune systems remains unclear. Previously, we reported FRP interacts with CD14, which is known to mediate toll-like receptor 4 (TLR4) signaling. Here, we investigated whether FRP activates TLR4 signaling. Recombinant FRP induced interleukin 6 or interleukin 8 production from target cells in a CD14- and TLR4-dependent manner. Moreover, similar to lipopolysaccharide (LPS), FRP induced tolerance to the second LPS stimulation. FRP has the function of evoking innate immune responses as one of the endogenous TLR4 agonists. |
