| First Author | Nagasaki H | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 4 | Pages | 368-72 |
| PubMed ID | 22245676 | Mgi Jnum | J:181938 |
| Mgi Id | MGI:5314453 | Doi | 10.1016/j.febslet.2012.01.001 |
| Citation | Nagasaki H, et al. (2012) Inflammatory changes in adipose tissue enhance expression of GPR84, a medium-chain fatty acid receptor: TNFalpha enhances GPR84 expression in adipocytes. FEBS Lett 586(4):368-72 |
| abstractText | In this study we aimed to identify the physiological roles of G protein-coupled receptor 84 (GPR84) in adipose tissue, together with medium-chain fatty acids (MCFAs), the specific ligands for GPR84. In mice, high-fat diet up-regulated GPR84 expression in fat pads. In 3T3-L1 adipocytes, co-culture with a macrophage cell line, RAW264, or TNFalpha remarkably enhanced GPR84 expression. In the presence of TNFalpha, MCFAs down-regulated adiponectin mRNA expression in 3T3-L1 adipocytes. Taken together, our results suggest that GPR84 emerges in adipocytes in response to TNFalpha from infiltrating macrophages and exacerbates the vicious cycle between adiposity and diabesity. |
