| First Author | Liu J | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 6 | Pages | 834-40 |
| PubMed ID | 22449968 | Mgi Jnum | J:182356 |
| Mgi Id | MGI:5315312 | Doi | 10.1016/j.febslet.2012.02.003 |
| Citation | Liu J, et al. (2012) Kruppel-like factor 4 inhibits the expression of interleukin-1 beta in lipopolysaccharide-induced RAW264.7 macrophages. FEBS Lett 586(6):834-40 |
| abstractText | RAW264.7 macrophages and human peripheral blood mononuclear cells were treated with LPS to determine the expression of KLF4 and release of IL-1beta. A full-length cDNA or short interference RNA of KLF4 was transfected into RAW264.7 macrophages; the expression and release of IL-1beta were analyzed. The transcription and DNA binding activities of KLF4 to the IL-1beta promoter were detected further. The results showed LPS treatment resulted in the increase of KLF4 level and IL-1beta release; KLF4 overexpression decreased the expression of IL-1beta, while KLF4 inhibition increased the expression of IL-1beta; overexpression of KLF4 promoted the DNA binding activity of KLF4 to the IL-1beta promoter and attenuated the transcription of IL-1beta promoter, indicating an important role of KLF4 in regulating expression of IL-1beta. |
