| First Author | Kamemura K | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 9 | Pages | 1379-83 |
| PubMed ID | 22504143 | Mgi Jnum | J:183928 |
| Mgi Id | MGI:5319571 | Doi | 10.1016/j.febslet.2012.03.060 |
| Citation | Kamemura K, et al. (2012) Depression of mitochondrial metabolism by downregulation of cytoplasmic deacetylase, HDAC6. FEBS Lett 586(9):1379-83 |
| abstractText | Mitochondria perform multiple functions critical to the maintenance of cellular homeostasis. Here we report that the downregulation of histone deacetylase 6 (HDAC6) causes a reduction in the net activity of mitochondrial enzymes, including respiratory complex II and citrate synthase. HDAC6 deacetylase and ubiquitin-binding activities were both required for recovery of reduced mitochondrial metabolic activity due to the loss of HDAC6. Hsp90, a substrate of HDAC6, localizes to mitochondria and partly mediates the regulation of mitochondrial metabolic activity by HDAC6. Our finding suggests that HDAC6 regulates mitochondrial metabolism and might serve as a cellular homeostasis surveillance factor. |
