| First Author | Zhang L | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 7 | Pages | 996-1003 |
| PubMed ID | 22569253 | Mgi Jnum | J:184515 |
| Mgi Id | MGI:5424271 | Doi | 10.1016/j.febslet.2012.02.027 |
| Citation | Zhang L, et al. (2012) Activating cardiac E2F1 induces up-regulation of pyruvate dehydrogenase kinase 4 in mice on a short term of high fat feeding. FEBS Lett 586(7):996-1003 |
| abstractText | A high fat diet (HFD) induces substantial cardiac metabolic alteration(s), but the initiating molecular events remain unclear. We assessed the early cardiac energy metabolic changes in C57/BJ mice fed a HFD for 10days. Carbohydrate oxidation was markedly decreased in mice on a HFD, in which up-regulation of pyruvate dehydrogenase kinase 4 (PDK4) was evident. Concurrently, E2F1, a transcription factor controlling PDK4 expression, was activated, as was cyclin D1, an upstream-molecule of E2F1, and eukaryotic initiation factor 4E (eIF4E), a modulator of cyclinD1 translation. Hence, HFD may initiate early cardiac metabolic alterations through the eIF4E/cyclin D1/E2F1/PDK4 axis. |
