| First Author | Hacker C | Year | 2003 |
| Journal | Nat Immunol | Volume | 4 |
| Issue | 4 | Pages | 380-6 |
| PubMed ID | 12598895 | Mgi Jnum | J:189415 |
| Mgi Id | MGI:5445492 | Doi | 10.1038/ni903 |
| Citation | Hacker C, et al. (2003) Transcriptional profiling identifies Id2 function in dendritic cell development. Nat Immunol 4(4):380-6 |
| abstractText | Dendritic cells (DCs) are potent antigen-presenting cells with a pivotal role in antigen-specific immune responses. Here, we found that the helix-loop-helix transcription factor Id2 is up-regulated during DC development in vitro and crucial for the development of distinct DC subsets in vivo. Id2-/- mice lack Langerhans cells (LCs), the cutaneous contingent of DCs, and the splenic CD8alpha+ DC subset is markedly reduced. Mice deficient for transforming growth factor (TGF)-beta also lack LCs, and we demonstrate here that, in DCs, TGF-beta induces Id2 expression. We also show that Id2 represses B cell genes in DCs. These findings reveal a TGF-beta-Id2 signaling pathway in DCs and suggest a mechanism by which Id2 affects the lineage choice of B cell and DC progenitors. |
