| First Author | Oliveira AM | Year | 2012 |
| Journal | Nat Neurosci | Volume | 15 |
| Issue | 8 | Pages | 1111-3 |
| PubMed ID | 22751036 | Mgi Jnum | J:190083 |
| Mgi Id | MGI:5447919 | Doi | 10.1038/nn.3151 |
| Citation | Oliveira AM, et al. (2012) Rescue of aging-associated decline in Dnmt3a2 expression restores cognitive abilities. Nat Neurosci 15(8):1111-3 |
| abstractText | Cognitive abilities decline in normal aging, yet the underlying molecular mechanisms are poorly understood. We found that aging was associated with a decrease in the expression of the DNA methyltransferase Dnmt3a2 in the hippocampus and that rescuing Dnmt3a2 levels restored cognitive functions. Moreover, we found that Dnmt3a2 is an activity-regulated immediate early gene that is partly dependent on nuclear calcium signaling and that hippocampal Dnmt3a2 levels determine cognitive abilities in both young adult and aged mice. |
