| First Author | Çobanoğlu G | Year | 2012 |
| Journal | Biochem Biophys Res Commun | Volume | 427 |
| Issue | 1 | Pages | 1-4 |
| PubMed ID | 22982304 | Mgi Jnum | J:190122 |
| Mgi Id | MGI:5448100 | Doi | 10.1016/j.bbrc.2012.08.103 |
| Citation | Cobanoglu G, et al. (2012) Are alsin and spartin novel interaction partners?. Biochem Biophys Res Commun 427(1):1-4 |
| abstractText | Mutations in ALS2 gene/alsin are associated with recessive forms of motor neuron disorders including Juvenile Amyotrophic Lateral Sclerosis (JALS), Infantile-onset Ascending Hereditary Spastic Paraplegia (IAHSP) and Juvenile Primary Lateral Sclerosis (JPLS). In this study, we show that alsin and another MND-linked protein, spartin are related to each other both at mRNA and protein levels in Neuro2a cells. We observed significant alterations in spartin expression in alsin knock-down conditions. We further found that both proteins colocalize in N2a cells and spartin isoform-a precipitates with alsin in the same protein complex. In the light of these results we suggest that alsin and spartin may interact each other physically. |
