| First Author | Qi Q | Year | 2011 |
| Journal | FEBS J | Volume | 278 |
| Issue | 12 | Pages | 1970-9 |
| PubMed ID | 21362141 | Mgi Jnum | J:190801 |
| Mgi Id | MGI:5449703 | Doi | 10.1111/j.1742-4658.2011.08074.x |
| Citation | Qi Q, et al. (2011) Tec family kinases: Itk signaling and the development of NKT alphabeta and gammadelta T cells. FEBS J 278(12):1970-9 |
| abstractText | The Tec family tyrosine kinase interleukin-2 inducible T-cell kinase (Itk) is predominantly expressed in T cells and has been shown to be critical for the development, function and differentiation of conventional alphabeta T cells. However, less is known about its role in nonconventional T cells such as NKT and gammadelta T cells. In this minireview, we discuss evidence for a role for Itk in the development of invariant NKT alphabeta cells, as well as a smaller population NKT-like gammadelta T cells. We discuss how these cells take what could be the same signaling pathway regulated by Itk, and interpret it to give different outcomes with regards to development and function. |
