| First Author | Sawada J | Year | 2012 |
| Journal | Cancer Cell | Volume | 22 |
| Issue | 2 | Pages | 235-49 |
| PubMed ID | 22897853 | Mgi Jnum | J:191821 |
| Mgi Id | MGI:5463165 | Doi | 10.1016/j.ccr.2012.06.013 |
| Citation | Sawada J, et al. (2012) Small GTPase R-Ras regulates integrity and functionality of tumor blood vessels. Cancer Cell 22(2):235-49 |
| abstractText | We show that R-Ras, a small GTPase of the Ras family, is essential for the establishment of mature, functional blood vessels in tumors. The genetic disruption of R-Ras severely impaired the maturation processes of tumor vessels in mice. Conversely, the gain of function of R-Ras improved vessel structure and blood perfusion and blocked plasma leakage by enhanced endothelial barrier function and pericyte association with nascent blood vessels. Thus, R-Ras promotes normalization of the tumor vasculature. These findings identify R-Ras as a critical regulator of vessel integrity and function during tumor vascularization. |
