| First Author | Aoyama E | Year | 2012 |
| Journal | FEBS Lett | Volume | 586 |
| Issue | 24 | Pages | 4270-5 |
| PubMed ID | 23142580 | Mgi Jnum | J:192362 |
| Mgi Id | MGI:5464969 | Doi | 10.1016/j.febslet.2012.10.038 |
| Citation | Aoyama E, et al. (2012) CCN2/CTGF binds to fibroblast growth factor receptor 2 and modulates its signaling. FEBS Lett 586(24):4270-5 |
| abstractText | CCN2 plays a critical role in the development of mesenchymal tissues such as cartilage and bone, and the binding of CCN2 to various cytokines and receptors regulates their signaling.By screening a protein array, we found that CCN2 could bind to fibroblast growth factor receptors (FGFRs) 2 and 3, with a higher affinity toward FGFR2.We ascertained that FGFR2 bound to CCN2 and that the binding of FGFR2 to FGF2 and FGF4 was enhanced by CCN2.CCN2 and FGF2 had a collaborative effect on the phosphorylation of ERK and the differentiation of osteoblastic cells.The present results indicate the biological significance of the binding of CCN2 to FGFR2 in bone metabolism. |
