| First Author | Voloboueva LA | Year | 2013 |
| Journal | FEBS Lett | Volume | 587 |
| Issue | 6 | Pages | 756-62 |
| PubMed ID | 23395614 | Mgi Jnum | J:195331 |
| Mgi Id | MGI:5477901 | Doi | 10.1016/j.febslet.2013.01.067 |
| Citation | Voloboueva LA, et al. (2013) Inflammatory response of microglial BV-2 cells includes a glycolytic shift and is modulated by mitochondrial glucose-regulated protein 75/mortalin. FEBS Lett 587(6):756-62 |
| abstractText | Recent studies suggest a link between mitochondria and proinflammatory cytokine generation. We previously demonstrated that overexpression of mitochondrial chaperone glucose-regulated protein75 (Grp75/mortalin) protects mitochondria. In this study we investigated the modulation of the lipopolisaccharide (LPS)-induced inflammatory response of microglial BV-2 cells by Grp75. We demonstrate that LPS-induced activation promotes significant metabolic changes suppressing mitochondrial function and increasing glycolysis. Overexpression of Grp75 attenuates the LPS-induced oxidative and metabolic responses, and suppresses proinflammatory activation, which depends on both NF-kappaB activation and lactate. Thus overexpression of Grp75 provides a novel strategy to modulate proinflammatory cytokine production of relevance to inflammation-associated pathologies. |
