| First Author | Lin GL | Year | 2013 |
| Journal | FEBS Lett | Volume | 587 |
| Issue | 6 | Pages | 763-9 |
| PubMed ID | 23395612 | Mgi Jnum | J:195332 |
| Mgi Id | MGI:5477902 | Doi | 10.1016/j.febslet.2013.01.068 |
| Citation | Lin GL, et al. (2013) Activation of beta 1 but not beta 3 integrin increases cell traction forces. FEBS Lett 587(6):763-9 |
| abstractText | Cell-generated traction forces induce integrin activation, leading to focal adhesion growth and cell spreading. It remains unknown, however, whether integrin activation feeds back to impact the generation of cytoskeletal tension. Here, we used elastomeric micropost arrays to measure cellular traction forces in wildtype and integrin-null cells. We report that activation of beta1 but not beta3 integrin, by either increasing density of immobilized fibronectin or treating with manganese, elicited fibroblast spreading and cytoskeletal tension. Furthermore, this force generation required Rho kinase and myosin activity. These findings suggest that integrin activation and cell traction forces comprise a bi-directional signaling unit of cell adhesion. |
