| First Author | Hong HY | Year | 2013 |
| Journal | Biochem Biophys Res Commun | Volume | 432 |
| Issue | 1 | Pages | 193-7 |
| PubMed ID | 23375543 | Mgi Jnum | J:198058 |
| Mgi Id | MGI:5495347 | Doi | 10.1016/j.bbrc.2012.12.123 |
| Citation | Hong HY, et al. (2013) 14-3-3 sigma is a new target up-regulated by transforming growth factor-beta1 through a Smad3-dependent mechanism. Biochem Biophys Res Commun 432(1):193-7 |
| abstractText | The seven members of the human 14-3-3 family play crucial roles in a diverse range of cellular responses including cell cycle progression, DNA damage checkpoint, and apoptosis. One particular isoform, 14-3-3 sigma, the p53 target gene, is a unique tumor suppressor. We here report 14-3-3 sigma as a transforming growth factor-beta (TGF-beta) target gene. In mammary epithelial cells, TGF-beta selectively induced expression of 14-3-3 sigma at both mRNA and protein levels, and this induction was dependent on Smad3 not on p53. In addition, blockade of non-canonical Smad-independent pathways, including MAP kinases and Rho GTPases, did not affect the TGF-beta1-induced 14-3-3 sigma expression. Our data provides the first evidence that 14-3-3 sigma is a Smad3-dependent target gene of TGF-beta1. |
