| First Author | Wakefield LM | Year | 2013 |
| Journal | Nat Rev Cancer | Volume | 13 |
| Issue | 5 | Pages | 328-41 |
| PubMed ID | 23612460 | Mgi Jnum | J:198445 |
| Mgi Id | MGI:5496748 | Doi | 10.1038/nrc3500 |
| Citation | Wakefield LM, et al. (2013) Beyond TGFbeta: roles of other TGFbeta superfamily members in cancer. Nat Rev Cancer 13(5):328-41 |
| abstractText | Much of the focus on the transforming growth factor-beta (TGFbeta) superfamily in cancer has revolved around the TGFbeta ligands themselves. However, it is now becoming apparent that deregulated signalling by many of the other superfamily members also has crucial roles in both the development of tumours and metastasis. Furthermore, these signalling pathways are emerging as plausible therapeutic targets. Their roles in tumorigenesis frequently reflect their function in embryonic development or in adult tissue homeostasis, and their influence extends beyond the tumours themselves, to the tumour microenvironment and more widely to complications of cancer such as cachexia and bone loss. |
