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Publication : Leptin at the intersection of neuroendocrinology and metabolism: current evidence and therapeutic perspectives.

First Author  Dalamaga M Year  2013
Journal  Cell Metab Volume  18
Issue  1 Pages  29-42
PubMed ID  23770129 Mgi Jnum  J:199243
Mgi Id  MGI:5501365 Doi  10.1016/j.cmet.2013.05.010
Citation  Dalamaga M, et al. (2013) Leptin at the intersection of neuroendocrinology and metabolism: current evidence and therapeutic perspectives. Cell Metab 18(1):29-42
abstractText  Since its discovery as an adipocyte-secreted hormone, leptin has been found to impact food intake, energy homeostasis, and metabolism through its effects on the central nervous system and peripheral organs. Recent research indicates that leptin may also be involved in cognition, immune function, and bone metabolism. These findings place leptin at the intersection of neuroendocrinology and metabolism, and possibly immune function, and render it an appealing therapeutic target for several niche areas of unmet clinical need. Current evidence regarding classic and emerging roles of leptin as well as the pros and cons of its potential clinical use are summarized herein.
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