| First Author | Ghosh A | Year | 2013 |
| Journal | Cancer Res | Volume | 73 |
| Issue | 15 | Pages | 4687-96 |
| PubMed ID | 23733752 | Mgi Jnum | J:199472 |
| Mgi Id | MGI:5502824 | Doi | 10.1158/0008-5472.CAN-12-4699 |
| Citation | Ghosh A, et al. (2013) PLZF Confers Effector Functions to Donor T Cells That Preserve Graft-versus-Tumor Effects while Attenuating GVHD. Cancer Res 73(15):4687-4696 |
| abstractText | Efforts to limit GVHD mediated by alloreactive donor T cells after allogeneic bone marrow transplantation are limited by a concomitant decrease in graft-versus-tumor (GVT) activity and increased possibilities of tumor relapse. Using a novel approach, we adoptively transferred conventional T cells expressing the transcription factor promyelocytic leukemia zinc finger (PLZF), which confers effector properties resembling invariant natural killer T cells, such as copious production of cytokines under suboptimal stimulation. PLZF expression in T-cell allografts attenuates expansion of alloreactive T cells, leading to lower GVHD. Intact alloreactivity-driven antitumor cytokine responses result in preserved GVT effects, leading to improved survival. Our findings suggest that therapy with PLZF-overexpressing T cells would result in overall improved outcomes due to less GVHD and intact GVT effects. Cancer Res; 73(15); 4687-96. (c)2013 AACR. |
