First Author | Otto T | Year | 2013 |
Journal | Cancer Cell | Volume | 24 |
Issue | 2 | Pages | 141-3 |
PubMed ID | 23948293 | Mgi Jnum | J:202613 |
Mgi Id | MGI:5520117 | Doi | 10.1016/j.ccr.2013.07.019 |
Citation | Otto T, et al. (2013) The kinase-independent, second life of CDK6 in transcription. Cancer Cell 24(2):141-3 |
abstractText | CDK6 is an oncogenic kinase regulating the cell cycle. In this issue of Cancer Cell, Kollmann and colleagues demonstrate that CDK6 performs a kinase-independent transcriptional function in regulating expression of VEGF-A and p16INK4a. These observations link the cell cycle machinery and angiogenesis and reveal the presence of a fail-safe antiproliferative mechanism. |