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Publication : The kinase-independent, second life of CDK6 in transcription.

First Author  Otto T Year  2013
Journal  Cancer Cell Volume  24
Issue  2 Pages  141-3
PubMed ID  23948293 Mgi Jnum  J:202613
Mgi Id  MGI:5520117 Doi  10.1016/j.ccr.2013.07.019
Citation  Otto T, et al. (2013) The kinase-independent, second life of CDK6 in transcription. Cancer Cell 24(2):141-3
abstractText  CDK6 is an oncogenic kinase regulating the cell cycle. In this issue of Cancer Cell, Kollmann and colleagues demonstrate that CDK6 performs a kinase-independent transcriptional function in regulating expression of VEGF-A and p16INK4a. These observations link the cell cycle machinery and angiogenesis and reveal the presence of a fail-safe antiproliferative mechanism.
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