| First Author | Cozzolino M | Year | 2013 |
| Journal | Mol Cell Neurosci | Volume | 55 |
| Pages | 44-9 | PubMed ID | 22705710 |
| Mgi Jnum | J:203599 | Mgi Id | MGI:5527512 |
| Doi | 10.1016/j.mcn.2012.06.001 | Citation | Cozzolino M, et al. (2013) Mitochondria and ALS: implications from novel genes and pathways. Mol Cell Neurosci 55:44-9 |
| abstractText | Evidence from patients with sporadic and familiar amyotrophic lateral sclerosis (ALS) and from models based on the overexpression of mutant SOD1 found in a small subset of patients, clearly point to mitochondrial damage as a relevant facet of this neurodegenerative condition. In this mini-review we provide a brief update on the subject in the light of newly discovered genes (such as TDP-43 and FUS/TLS) associated to familial ALS and of a deeper knowledge of the mechanisms of derangement of mitochondria. This article is part of a Special Issue entitled 'Mitochondrial function and dysfunction in neurodegeneration'. |
