| First Author | Lee Y | Year | 2013 |
| Journal | Bone | Volume | 56 |
| Issue | 2 | Pages | 383-9 |
| PubMed ID | 23867221 | Mgi Jnum | J:203705 |
| Mgi Id | MGI:5528577 | Doi | 10.1016/j.bone.2013.07.007 |
| Citation | Lee Y, et al. (2013) MicroRNA-124 regulates osteoclast differentiation. Bone 56(2):383-9 |
| abstractText | Osteoclasts are specialized cells for bone-resorption originated from precursors of macrophage/monocyte lineage. The receptor activator of NFkappaB ligand (RANKL) initiates osteoclast differentiation, in which nuclear factor of activated T cell cytoplasmic 1 (NFATc1) plays a key role as a master transcription factor. In the present report, we show that microRNA-124 (miR-124) regulates osteoclastogenesis of mouse bone marrow macrophages (BMMs) by suppressing NFATc1 expression. On the other hand, synthetic inhibitor that binds specifically to miR-124 enhanced osteoclast differentiation and NFATc1 expression. The overexpression of a constitutively active form of NFATc1 prevented the inhibitory effect of miR-124 on osteoclastogenesis. Finally, miR-124 also affected the proliferation and motility of osteoclast precursors, the latter coinciding with the reduced expression of RhoA and Rac1. These findings not only reveal unprecedented role of miR-124 in osteoclastogenesis but also suggest a novel mode of regulation of NFATc1 in osteoclasts. |
