| First Author | Kang J | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 1 | Pages | 79-85 |
| PubMed ID | 24269680 | Mgi Jnum | J:205190 |
| Mgi Id | MGI:5544353 | Doi | 10.1016/j.febslet.2013.11.009 |
| Citation | Kang J, et al. (2014) A FoxO1-dependent, but NRF2-independent induction of heme oxygenase-1 during muscle atrophy. FEBS Lett 588(1):79-85 |
| abstractText | Skeletal muscle plays key roles in metabolic homeostasis. Loss of muscle mass, called muscle atrophy exacerbates disease-associated metabolic perturbations. In this study, we characterized the molecular functions and mechanisms underlying regulation of skeletal muscle atrophy induced by denervation. Denervation significantly increased the expression of heme oxygenase-1 (HO-1) and atrogenes in skeletal muscle. Forkhead box protein O1 (FoxO1) drastically increased in atrophied muscle and selectively stimulated HO-1 gene transcription through direct DNA binding. Lack of HO-1 substantially attenuated muscle atrophy, whereas HO-1 overexpression caused muscle damage in vitro and in vivo. Collectively, HO-1 induced by FoxO1 may cause skeletal muscle atrophy. |
