| First Author | McCoy F | Year | 2013 |
| Journal | Mol Cell | Volume | 52 |
| Issue | 3 | Pages | 325-39 |
| PubMed ID | 24095281 | Mgi Jnum | J:206000 |
| Mgi Id | MGI:5547644 | Doi | 10.1016/j.molcel.2013.08.043 |
| Citation | McCoy F, et al. (2013) Metabolic activation of CaMKII by coenzyme A. Mol Cell 52(3):325-39 |
| abstractText | Active metabolism regulates oocyte cell death via calcium/calmodulin-dependent protein kinase II (CaMKII)-mediated phosphorylation of caspase-2, but the link between metabolic activity and CaMKII is poorly understood. Here we identify coenzyme A (CoA) as the key metabolic signal that inhibits Xenopus laevis oocyte apoptosis by directly activating CaMKII. We found that CoA directly binds to the CaMKII regulatory domain in the absence of Ca(2+) to activate CaMKII in a calmodulin-dependent manner. Furthermore, we show that CoA inhibits apoptosis not only in X. laevis oocytes but also in Murine oocytes. These findings uncover a direct mechanism of CaMKII regulation by metabolism and further highlight the importance of metabolism in preserving oocyte viability. |
