| First Author | Kim Y | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 4 | Pages | 625-31 |
| PubMed ID | 24440351 | Mgi Jnum | J:206445 |
| Mgi Id | MGI:5550297 | Doi | 10.1016/j.febslet.2014.01.008 |
| Citation | Kim Y, et al. (2014) C-reactive protein induces G2/M phase cell cycle arrest and apoptosis in monocytes through the upregulation of B-cell translocation gene 2 expression. FEBS Lett 588(4):625-31 |
| abstractText | We hypothesized that C-reactive protein (CRP) may affect the cell cycle and induce apoptotic changes of monocytes. CRP ( approximately 25mug/ml) significantly increased expressions of B-cell translocation gene 2 (BTG2) mRNA and protein in human monocytes through pathways involving CD32/NADPH oxidase 2/p53, which eventually induced G2/M phase arrest and apoptotic cell death. Such pro-apoptotic effect of CRP was not found in thioglycollate-elicited intraperitoneal monocytes/macrophages harvested from BTG2-knockout male C57BL/6 mice (n=5). Within atheromatous plaques obtained from CRP-transgenic male LDLR(-/-) C57BL/6 mice (n=5) and human coronary arteries, BTG2 co-localized with CRP, p53 and monocytes/macrophages. Therefore the pro-apoptotic pathway of CRP-CD32-Nox2-p53-BTG2 may contribute to the retardation of the atherogenic process. |
