| First Author | Rech AJ | Year | 2013 |
| Journal | Cancer Discov | Volume | 3 |
| Issue | 12 | Pages | 1330-2 |
| PubMed ID | 24327693 | Mgi Jnum | J:208370 |
| Mgi Id | MGI:5562983 | Doi | 10.1158/2159-8290.CD-13-0775 |
| Citation | Rech AJ, et al. (2013) Dynamic interplay of oncogenes and T cells induces PD-L1 in the tumor microenvironment. Cancer Discov 3(12):1330-2 |
| abstractText | Tumor-infiltrating T cells have recently been found to upregulate immunosuppressive pathways, such as programmed cell death protein 1 ligand 1 (PD-L1), in a paracrine fashion on tumor cells, but tumor cell-intrinsic regulation of PD-L1 is another potential mechanism. In this issue of Cancer Discovery, Akbay and colleagues show that signaling via mutant EGF receptor (EGFR) in murine lung tumor cells directly upregulates tumor PD-L1 and that therapeutic blockade of this pathway improves survival in EGFR-driven preclinical models-highlighting the dynamic interplay and therapeutic opportunities of cancer cell biology and immune biology. |
