| First Author | Boudoukha S | Year | 2014 |
| Journal | FEBS Lett | Volume | 588 |
| Issue | 9 | Pages | 1623-9 |
| PubMed ID | 24613920 | Mgi Jnum | J:208403 |
| Mgi Id | MGI:5563264 | Doi | 10.1016/j.febslet.2014.02.057 |
| Citation | Boudoukha S, et al. (2014) MiRNA let-7g regulates skeletal myoblast motility via Pinch-2. FEBS Lett 588(9):1623-9 |
| abstractText | Post-transcriptional regulation of gene expression by RNA-binding proteins and by small non-coding RNAs plays an important role in cell biology. Our previous results show that in murine skeletal myoblasts, the expression of Pinch-2, a focal adhesion remodeling factor that regulates cell motility, is repressed by an RNA-binding protein IMP-2/Igf2bp2. We now show that the expression of Pinch-2 is also regulated by the miRNA let-7g. Let-7g and IMP-2 repress Pinch-2 expression independently of each other. A knock-down of let-7g leads to an increase in Pinch-2 expression, and to a decrease of cell motility, which can be reversed by a simultaneous knock-down of Pinch-2. We conclude that let-7g controls the motility of mouse myoblasts in cell culture by post-transcriptionally regulating the expression of Pinch-2. |
